ParkinsonV1, Main, Exploration, bibRecord, 001A70

Examination of motor output pathways in patients with corticobasal ganglionic degeneration using transcranial magnetic stimulation

Identifieur interne : 001A70 ( Main/Exploration ); précédent : 001A69; suivant : 001A71

Examination of motor output pathways in patients with corticobasal ganglionic degeneration using transcranial magnetic stimulation

Auteurs : Josep Valls-Sole [Espagne] ; Eduardo Tolosa [Espagne] ; Maria J. Marti [Espagne] ; Francesc Valldeoriola [Espagne] ; Marian Revilla [Espagne] ; Pau Pastor [Espagne] ; Rafael Blesa [Espagne]

Source :

Brain [ 0006-8950 ] ; 2001-06.

RBID : ISTEX:6BBB5FE4137A62BBED4C8B3284D0B136313BAF06

English descriptors

KwdEn :
- AHS = alien hand sign, CBGD = corticobasal ganglionic degeneration, MEP = motor evoked potential, TMS = transcranial cortical magnetic stimulation, alien hand, cortical map, corticobasal ganglionic degeneration, ipsilateral motor evoked potentials, transcranial magnetic stimulation.

Abstract

The alien hand sign (AHS) is often encountered in patients with corticobasal ganglionic degeneration (CBGD), revealing a unilateral dysfunction of the motor system of unknown pathophysiology. We examined the possibility of an abnormal cortical representation of hand muscles in 10 patients with probable CBGD and a prominent AHS. Cortical maps were obtained from the responses to magnetic stimuli applied with a figure of eight coil at an intensity of 110% above motor threshold. For comparison, the same study was carried out in 10 normal volunteers, eight patients with Parkinson's disease and eight patients with Alzheimer's disease. AHS patients had a larger extension of the cortical map to stimulation of the hemisphere contralateral to the AHS in comparison with the ipsilateral hemisphere. Furthermore, in six patients, focal stimulation of the hemisphere ipsilateral to the AHS gave rise to ipsilateral responses, delayed by a mean of 7.7 ± 2.2 ms with respect to those recorded in the same muscle to contralateral stimulation. None of the other patients or control subjects had ipsilateral responses. Our results indicate an enhanced excitability, or reduced inhibition, of the motor area of the hemisphere contralateral to the AHS. The delay of the ipsilateral responses is compatible with a disinhibited transcallosal input.

Url:

https://api.istex.fr/document/6BBB5FE4137A62BBED4C8B3284D0B136313BAF06/fulltext/pdf

DOI: 10.1093/brain/124.6.1131

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 001288
to stream Main, to step Curation: 001082

Le document en format XML

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<front><div type="abstract" xml:lang="en">The alien hand sign (AHS) is often encountered in patients with corticobasal ganglionic degeneration (CBGD), revealing a unilateral dysfunction of the motor system of unknown pathophysiology. We examined the possibility of an abnormal cortical representation of hand muscles in 10 patients with probable CBGD and a prominent AHS. Cortical maps were obtained from the responses to magnetic stimuli applied with a figure of eight coil at an intensity of 110% above motor threshold. For comparison, the same study was carried out in 10 normal volunteers, eight patients with Parkinson's disease and eight patients with Alzheimer's disease. AHS patients had a larger extension of the cortical map to stimulation of the hemisphere contralateral to the AHS in comparison with the ipsilateral hemisphere. Furthermore, in six patients, focal stimulation of the hemisphere ipsilateral to the AHS gave rise to ipsilateral responses, delayed by a mean of 7.7 ± 2.2 ms with respect to those recorded in the same muscle to contralateral stimulation. None of the other patients or control subjects had ipsilateral responses. Our results indicate an enhanced excitability, or reduced inhibition, of the motor area of the hemisphere contralateral to the AHS. The delay of the ipsilateral responses is compatible with a disinhibited transcallosal input.</div>
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Examination of motor output pathways in patients with corticobasal ganglionic degeneration using transcranial magnetic stimulation

Examination of motor output pathways in patients with corticobasal ganglionic degeneration using transcranial magnetic stimulation

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri